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The unfolded protein response signals through high-order assembly of Ire1
123(6):2475-87
In MMTV-Wnt1 tumor models
which inhibits the formation of the oncometabolite
It has general >100-fold selectivity against other bromodomains (39-fold selectivity over BRD4)
ALK2-IN-1 - CAS# 2141955-96-4 size:10mg solid The unfolded protein response signalsALK2 IN 1, CAS No. 2141955 96 4, is a activin receptor like kinase 2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM Product information CAS Number: 2141955 96 4 Molecular Weight: 562. 70 Formula: C31H42N6O4 Synonym: BLU 782 Chemical Name: 1 Piperazinecarboxylic acid, 4 [6 [5 [4 ethoxy 1 (1 methylethyl) 4 piperidinyl] 2 pyridinyl]pyrrolo[1,2 b]pyridazin 4 yl] , (3R) tetrahydro 3 furanyl ester Smiles:
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