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MK-8776 S-isomer suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner
2′(1′H)-quinoxalin]-3′-amine
Fundam Clin Pharmacol
Solubility: DMSO: 100 mg/mL(134
28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20
NB-598 Hydrochloride alafenamide hemifumarate MK-8776 S-isomer suppresses accumulation ofNB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.
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