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CAS Number: 157115-85-0
Smiles: C[C@H](NC(=O)O[C@@H](CC#N)CC)C1=CC(=CC=C1)NC(=O)NC1=CC(OC)=C(C=C1)C1=CN=CO1
5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide
Solubility: DMSO: 39 mg/mL(198
Inhibition of mitotic microtubules correlates with antitumor activity
Ro 48-8071 fumarate - CAS# 189197-69-1 Size:Solid 10 mg CAS Number: 157115-85-0Ro 48 8071 is an orally active cholesterol synthesis inhibitor or a 2,3 oxidosqualene: lanosterol cyclase (OSC) inhibitor. OSC (EC 5. 4. 99. 7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG CoA reductase expression, generating a synergistic, self limited negative regulatory loop.
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