ARRY-520 - CAS# 885060-09-3 azone Maleate Chemical Name: sodium2

Chemical Name: sodium2

Kopczynski C

Molecular Weight: 437

Smiles: CC1NC(=O)NC(C=1C(=O)NC1C=C2C=NNC2=CC=1)C1C=CC(F)=CC=1

10(8):1500-8

ARRY-520 - CAS# 885060-09-3 azone Maleate Chemical Name: sodium2Filanesib, also known as ARRY 520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY 520 specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic