Merbarone 479R)-Pirtobrutinib A-83-01 was found to be

A-83-01 was found to be more potent in the inhibition of ALK5 than a previously described ALK-5 inhibitor

and 22Rv1 cells at 10 µM

3-dimethylimidazo[1

InChi: InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H

Formula: C18H11Cl2N3O3S3

Merbarone 479R)-Pirtobrutinib A-83-01 was found to beMerbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II mediated DNA cleavage without stabilizing topo II DNA covalent complexes. Merbarone is an anticancer agent. Product information CAS Number: 97534 21 9 Molecular Weight: 263. 27 Formula: C11H9N3O3S Chemical Name: 4,6 dioxo N phenyl 2 sulfanylidene 1,3 diazinane 5 carboxamide Smiles: O=C(NC1C=CC=CC=1)C1C(=O)NC(=S)NC1=O