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PMID: 28381571
These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes
Formula: C18H12F6N6O
AR231453 can stimulate β-cell replication and improve islet graft function
Pomalidomide4-alkylC8
BI-3406 Size:10mg solid PMID: 28381571BI 3406 is Potent & Selective SOS1:: KRAS Inhibitor (IC50=5 nM), which Opens a New Approach for Treating KRAS Driven Tumours. BI 3406 selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. BI 3406 causes RAS GTP and pERK reduction and inhibits cell growth of KRAS mutated cell lines, carrying most of the typical KRAS mutations (i. e. G12D, G12V, G13D and others). BI 3406, when administered orally to tumour
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