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Smiles: CO[C@@H]1[C@@H](CO)O[C@H]([C@@H]1O)N1C=NC2=C1NC(N)=NC2=O
Chemical Name: 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
Smiles: CN(CCO)C(=O)C1C=C(N[C@@H]2CCOC3=CC=CC(C)=C32)C2=NC(C)=CN2C=1
AK-7 treatment resulted in improved motor function
2012(5):9–20
WH-4-023 denafil Hydrochloride Smiles: CO[C@@H]1[C@@H](CO)O[C@H]([C@@H]1O)N1C=NC2=C1NC(N)=NC2=OWH 4 023 is a potent and selective dual Lck Src inhibitor with IC50 of 2 nM 6 nM for Lck and Src kinase respectively. The lymphocyte specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Product
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