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PubMed Central PMCID: PMC5002914
Hussain MD
Formula: C19H16N2O2
Being function as a new class of human beta cell mitogenic compound
KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes
TUG-891 - CAS# 1374516-07-0 size:2mg solid PubMed Central PMCID: PMC5002914TUG 891, CAS No. 1374516 07 0, is a potent and selective agonist of the free fatty acid receptor 4 (FFA4 GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG 891 also resulted in rapid phosphorylation and internalization of the receptor. TUG 891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo