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The binding affinity of SJM-3 at wild type receptors is determined by displacement of [3H]-Flunitrazepam and [3H]-Ro15-1788 and indicates a Ki of SJM-3 amounting to 218±70 nM and 242±38 nM
Birth Defects Res B Dev Reprod Toxic
PMCID: PMC3797063
InChi: InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H
cIAP1 Ligand-Linker Conjugates 10 can be used to design SNIPERs
TAS6417 alaxyl-M The binding affinity of SJM-3TAS6417 (CLN 081) is a highly effective, orally active and pan mutation selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP binding site of the EGFR hinge region, with IC50 values ranging from 1. 1 8. 0 nM. Product information CAS Number: 1661854 97 2 Molecular Weight: 396. 44 Formula: C23H20N6O Chemical Name: N [(8S) 4 amino 6 methyl 5 (quinolin 3 yl) 8H,9H pyrimido[5,4 b]indolizin 8 yl]prop 2 enamide Smiles:
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