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HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis
The TAE684- (10 mg/kg) treated group appeares healthy and does not display any signs of compound- or disease-related toxicity
LY364947 (< 20 μM) suppresses leukaemia-initiating cells colony-forming ability after co-culture with OP-9 stromal cells
thereby inducing apoptosis of HER2-amplified breast cancer cells
4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile
Vacuolin-1 064 HS-173 decreased the expression HIF-1αVacuolin 1 is a potent and cell permeable inhibitor that blocks the Ca(2+) dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin 1 is also a potent and selective PIKfyve inhibitor, and inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. Product information CAS Number: 351986 85 1 Molecular Weight: 577. 42 Formula: C26H24IN7O Chemical Name: 3
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