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selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM
4 μM) with respect to Shh and as a noncompetitive inhibitor (Ki = 6
15)11-3-10-5/h1-3H
CAS Number: 56687-67-3
CAS Number: 116649-85-5
Atuveciclib (BAY-1143572) magacestat (LY450139) selective and orally active apoptosisAtuveciclib (BAY 1143572) is potent and highly selective PTEFb CDK9 inhibitor with IC50 values of 13 nM for CDK9 CycT and the ratio of IC50 values for CDK2 CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3 and GSK3 respectively. Product information CAS Number: 1414943 88 6 Molecular Weight: 387. 43 Formula: C18H18FN5O2S Chemical Name: [(3 {[4 (4 fluoro 2 methoxyphenyl) 1,3,5 triazin 2